Glossary

The following is a glossary of a number of the terms and acronyms which can be found within this document.

API
Active Principal Ingredient
Bio equivalence
The demonstration that the proposed formulation has the same biological effects as the pioneer product to which it is being compared. This is usually demonstrated by comparing blood concentrations of the active over time, but can be compared using a clinical endpoint (e.g. lowering of a worm count) for drugs that are not absorbed or for which blood levels cannot be determined.
CAP
Companion animal products
CE
Continuing Education
CMC
The Chemistry and Manufacturing Controls
Cortisol
A hormone which is made by the adrenal glands. Its production is increased during episodes of stress and it has many effects on the body. It helps regulate blood pressure, the immune system and helps balance the effect of insulin to keep the blood sugar at normal levels.
Cushing's Syndrome
A condition caused by excess cortisol (see above) and is named after the physician who first described the condition in humans in the early twentieth century.
Dechra Values or Values
Dedication, Enjoyment, Courage, Honesty, Relationships and Ambition
DPM
Dechra Pharmaceuticals Manufacturing
DVP EU
Dechra Veterinary Products EU
DVP US
Dechra Veterinary Products US
EBITDA
Earnings before interest, tax, depreciation and amortisation.
Euthyroid
Euthyroid is the state of having normal thyroid gland function.
Executive Directors
The Executive Directors of the Company, currently Ian Page, Anne-Francoise Nesmes, Ed Torr and Tony Griffin
FAP
Food animal producing products
FDA
US Food and Drug Administration; a federal agency of the US Department of Health and Human Services.
FRS
Financial Reporting Standards
FTSE250/350 Index
An index comprising of the 101st to 350th largest companies listed on the London Stock Exchange in terms of their market capitalisation
FTSE Small Cap Index
An index comprising of the 351st to 619th largest listed companies on the London Stock Exchange in terms of their market capitalisation
Hyperthyroidism
Occurs when the thyroid glands produce excessive amounts of thyroid hormone. This causes an increase in the animal's metabolism (the rate at which energy is utilised).
IAS
International Accounting Standards
IFRS
International Financial Reporting Standards
Intertrigo
Refers to a bacterial, fungal or viral infection that has developed at the site of broken skin due to inflammation of body folds. This infection is common in dogs with folds, such as Pugs or Shar Peis.
LIBOR
The London inter-bank offered rate
Malassezia
Yeasts that cause a secondary inflammatory skin disease. Malassezia is often found in otitis externa.
MHRA
Medicines and Healthcare products Regulatory Agency; an executive agency of the Department of Health.
MRL
Maximum residue level
NADA
New Animal Drug Application
Non-Executive Directors
The Non-executive Directors of the Company, currently Michael Redmond, Neil Warner, Dr Chris Richards, Julian Heslop and Ishbel Macpherson
NSAID
Non-Steroidal Anti-Inflammatory Drug; essentially drugs which relieve pain, swelling, stiffness and inflammation. Equipalazone is the leading NSAID for the treatment of musculoskeletal disorders in the horse.
Ordinary Shares
An ordinary share of 1 pence in the share capital of the Company
Otitis Externa
A condition which causes inflammation of the external ear canal (the tube between the outer ear and the ear drum).
PDRA
Dechra's Product Development and Regulatory Affairs team
Product Pipeline
This involves four stages which are as follows: MANUFACTURING — the part of the dossier which documents the quality, purity and physical characteristics of both the active ingredient and the final formulation (e.g. tablets, capsules, liquid). SAFETY — the part of the dossier which documents the effects of the final formulation at above normal dosage levels in the intended species. EFFICACY — the part of the dossier which documents the effectiveness of the final formulation in the intended species. The studies may be controlled model studies or studies in animals with the naturally occurring disease. REGULATORY — the period of time that regulatory agencies take to review the various sections of the dossier.
RIDDOR
Reporting of Injuries, Diseases and Dangerous Occurrences Regulations
Rights Issue
The three for ten rights issue of 20,040,653 shares, details of which are set out in the prospectus of the Company dated 25 April 2012.
SAYE
Save as You Earn Share Scheme
Shareholder
Holder of ordinary shares in Dechra
Staphylococcal Infections
Communicable conditions caused by the Staphylococcus type of bacteria and generally characterised by pyoderma or the formation of abscesses.
Surface Pyoderma
Pyoderma is the medical term used to denote infections of the skin caused by bacteria. Surface Pyoderma is a bacterial infection which is confined to the surface of the skin; one of the commonest types is known as Pyotraumatic Dermatitis (acute moist dermatitis, or "hot spots"). It is typified by localised itching, moist reddened skin patches and ulcerated lesions.
VCA
Veterinary Centres of America